Considering the influence of surface roughness,by using the average Reynolds equation based on the average flow model, the teeth lubrication appearance of harmonic gear drive was researched further. The calculation relationship between tooth face pressure and oil film thickness was deduced, the numerical solve of shear films and squeeze films was computed,the curves of teeth minimum oil film was given. The result shows when the teeth surface roughness is enlarged, the effect of hydrodynamic pressure lubrication it caused is strengthened, the lubrication oil of teeth is saved easily, the enough oil film can be established.